Dr Rajeev Khare was born and brought up in Indore, Madhya Pradesh. At King George University, Dr Khare received rigorous training in noninvasive and invasive cardiology. In the year 1996, he established an independently run clinic in Indore and worked as a freelancer in Cloth Market, Sai Baba, Gokul Das, and Vishesh Hospitals for around 15 years.