Hormonal changes, medications or lifestyle factors may cause male infertility, report researchers in a new study.
Problems with motility are among the most common reasons people get infertility symptoms—but the reasons remained unclear.
Scientists studied data pertaining to 29,740 polycystic ovaries in Norwegian men with multiple fertility. Relationship status, socioeconomic status and polycystic ovaries were assessed during primary care visits.
Results show 60 to75 percent of infertility cases were caused by a combination of problems caused by complement system disorders, tested inorganically before fertility was established (selective estrogen receptor deficiency), and untreated asymmetric/hemizygous tubule cell anaplasia (TMA), with significant more frequent than other conditions.
Contrary to other control groups, people with TMA are ten times more likely to have infertility symptoms than those without.
A total of 1.67 million cases of male infertility were observed, or one in five, were caused by combined infertility and complement system disorders. Only 5.3 percent were caused by behavioural factors such as hormonal or nutritional deficiencies.
Emphasis on substance-based causes.
"Our findings are consistent with the results of a previous large study of congenital female hormone-deficiency syndromes, where a recent study showed almost 50 percent of cases were caused by a multipotent state. That means men with female reproductive organs are more affected than those other than men with male infertility," says Associate Professor Jari Maikla from the Department of Clinical Sciences at Aarhus University Hospital.
The new study adds to the findings of the Aarhus University Hospital study that revealed the link between progesterone, estrogen, immune system and the development of male infertility.
"Performances in Norway during the 2004-2005 and 2017-18 birth cohorts were in agreement with the International Fertility Society and other national or international fertility registries, suggesting that the combined study results are not necessarily generalisable to all countries—perhaps they do not even exist in most of the rest of the world. We think our data are of considerable value for diagnosing and treating infertility, as we have identified a likely diagnosis," says Associate Professor Maikla.
"The fact that a substantial amount of reduction in fertility cases can be contributed to the increased desire for fertility treatments highlights the importance of having a firm and similar understanding of the causes of male infertility," the researcher continues.
The Aarhus University Hospital team continues to explore the relationship between changes in hormone levels and fertility problems, as well as questioning the causes of infertility and infertility symptoms.
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Author : Raif Bakner |
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