Amyotrophic Lateral Sclerosis, most commonly known as the Lou Gehrig's disease or motor neuron disease is a progressive neurological disease that causes gradual weakening and atrophy in muscles. This progression of the symptoms can go up to as many as two to five years. In some rare cases a person can live up to seven years with chances of 100% fatal outcome.
Our brain has a network of nerve cells known as neurons, which accurately act as a medium for signaling the important information originated from brain to different other parts of the body. The brain is portioned into different region for controlling and signaling different functions. Amyotrophic Lateral Sclerosis is the degeneration of neurons, in the motor region of the brain that controls voluntary movements. There are some factors such as excessive protein flakes deposition or external shocks or sometimes may be genetic mutations that are responsible for such degeneration due to which functionality of neurons to pass the signals to the muscles is lost or glitches . As muscles do not get any signal about movement from the brain, their function is interrupted and they become progressively weak.
Conventional treatment for ALS results in serious contraindications such as respiratory failure, various grades of artificial lung ventilations, dysphasia and also showed gastric stroma. Stem cells are the master cells of body , isolated from our own body, developed and differentiated in the laboratory and re-infused back into the body to grow on their full potential of differentiating into desired cell types. With more number of patients going for stem cells therapy for ALS, it has been observed from the post transplant data that infusion of stem cells, do not cure the immediate cause of the disease but have exerted influences on links of the pathological diseases and dimming down the disease progression.
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