Erectile Dysfunction |
Posted: August 18, 2019 |
Erectile dysfunction is a type of male sexual dysfunction that means that the erection is not enough to maintain a satisfactory sex life or that the erection is not maintained. It is also defined as erectile dysfunction if it persists for more than three months. In general, when men experience sexual stimulation, blood vessels in the penis expand and 4-11 times as much blood flows into the penis as usual. At the same time, by preventing blood from escaping, the penis becomes larger and erections occur. However, men suffering from erectile dysfunction may not have enough blood vessels to relax and the erectile dysfunction may occur due to the incomplete process of this process buy viagra online. Causes of Erectile dysfunction is classified into temperament caused by physical abnormalities and psychogenicity caused by mental problems. More than 50% are organic and the older the higher the rate of organicist. Aging is the most common cause of erectile dysfunction, including smoking, drinking alcohol, diabetes, high blood pressure, cerebrovascular disease. In addition, hormonal preparations, some antihypertensive drugs, and psychotropic drugs can also cause erectile dysfunction, and surgery and damage to the brain, spinal cord, and pelvis can also cause erectile dysfunction, including chronic sclerosis (brain, spinal cord, and optic nerve). Chronic neuroimmune diseases that occur in the central nervous system, including, depression, chronic renal failure and liver failure, chronic obstructive pulmonary disease, scleroderma (a disease that causes the skin to harden, etc.) may be the cause of erectile dysfunction. On the other hand, without such physical causes, psychological factors such as emotional stress, depression or anxiety disorder may also cause erectile dysfunction. Drug treatment as an Oral erectile dysfunction drug, 'Phosphodiesterase5 inhibitor' or 'PDE5 inhibitor' is used. The penis consists of sponge-like sponge tissue, and when the inner arteries are relaxed and the veins are constricted, the penis is erected by increasing the inflow of blood into the penis. In this process, cGMP (Cyclic guanosine monophosphate) relaxes the corpus cavernosum, increasing blood flow and consequently causing erections. PDE5 inhibitors treat erectile dysfunction by inhibiting the activity of PDE5 enzymes that break down cGMP. Do. Types include 'Sildenafil', 'Vardenafil' and 'Tadalafil', and 'Udenafil' and 'Mirodenafil' developed by domestic pharmaceutical companies. Sildenafil, vardenafil, and mirdenafil have strong penile stiffness, tadalafil for long duration, and udenafil for low frequency of side effects. In particular, 'tadalafil' is a drug that has attracted the attention of pharmaceutical companies since the patent expiration in September 2015. Tadalafil has a long half-life of 17.5 hours (half the time the body's blood drug level is reduced by half), which lasts 24 to 36 hours after taking it. In addition, since the drug expression time is short, it can be taken 30 minutes before sexual activity and has good drug resistance (tolerable side effects or discomfort when the patient takes the drug). It can be taken with or without a meal, and can be easily taken without water as well as general tablets. Common side effects of PDE5 inhibitors include peripheral vasodilation such as headache (15%), indigestion (4-10%), hot flashes (4-10%), nasal congestion (3%), and headache (3%) It is caused by and shows similar incidence in all drugs. Sildenafil, Vardenafil, and Eudenafil have cross-reactions with PDE6 (Phosphodiesterase6), which is similar to PDE5 compared to tadalafil, which can cause visual side effects such as blurred vision. Low back pain may occur occasionally. In addition to drug treatment, endocrine dysfunction, the effects of foods or concomitant medications, inadequate medication time, insufficient sexual stimulation, excessive alcohol intake, and problems with sexual partners can cause failure of treatment with PDE5 inhibitors. It is also important to address them beforehand.
|
||||||||||||||||||||||||||||||||||||||||||
|